Yes indeed - App Connect already have many of the Bootstrap components and much more, well integrated and also jQuery free
Also as we are integrating much more core CSS functionality as CSS grid - the need of Bootstrap will become less and less.
I see Bootstrap more as a transition helper till the browsers get it right. Just like jQuery was long time ago.
So as the browsers progress together with the CSS standards, the need for frameworks like Bootstrap will become less.
But we are not there yet might take a couple of years