Except real time apps and a few other features I could say if I thought about it hard enough you can basically do anything with standard Wappler components in regards to final result.
And while final result may be sufficient for some and it is where Wappler excels I might want to arrive to a similar result using a different path. So I decide to use another approach by building it myself or using a third party library.
And surprise, surprise...Wappler provides a great framework to interact with. You can check my latest integration to see what I mean.
Just joking 
There are certain libraries that due to their nature(like real-time capability) can't be or don't make sense to integrate with PHP or ASP. Therefore there will be some server actions available only to Nodejs server model.