Actually this would be indeed possible with the new NodeJS integration 
Just as we do in Wappler you can run the lite nodejs server inside your desktop app!
So you will have a full blown desktop app with all the client and server side functionality all in one!
The enduser will never notice any difference as the local web server will be auto started and stopped together with the app and will be hidden as it is just for internal use.
And indeed a great choice with this will be SQLite integration as local database. So that you have everything you need to build an offline desktop app!
We already support SQLite out of the box in NodeJS - so you can already connect and manage it.
So all the ingredients are in there - we just have to combine it with Electron for packaging so you have it all in one